Early Development

Indication Optimisation

Problem

Company wished to develop a novel Phase I pain compound globally in the most commercially-viable initial indication and optimise subsequent launch sequence

Solution

Analysed current treatment pricing and reimbursement, development pipeline, as well as real-world evidence around unmet need and treatments patterns in over 10 different possible indications to determine initial indication with greatest value.  Validated assumptions with external payers, KOLs, and regulatory bodies, as well as internal experts.  Recommended life-cycle management opportunities post initial launch

Impact

Obtained buy-in from internal stakeholders across regions and aligned organisation around the lead indication and optimal development pathway

Social Media Mining

Problem

Company interested in generating potential indications of unmet need for repurposing of an existing compound

Solution

Brainstormed potential data sources, arriving at social media given its efficiency in collection, analysis and untapped potential.  Mined social media data for positive sentiments of the compound alongside mentions of organs/body parts and positive effects not within current licensed indications

Impact

Provided a list of possible indications to explore with further analysis and studies

Value Assessment Model

Problem

Company considering acquiring the rights to a new treatment for a rare disease with little experience in value-based pricing and health economics

Solution

Reviewed disease area literature to understand quality of life and costs, benefit of treatment, as well as market share and revenue forecasts.  Developed an integrated value assessment model (VAM) that allowed the team to test changes in the target product profile and pricing methodology on the overall value

 

Impact

Provided a clear understanding of the direct impact on financial value from changes to product characteristics, as well as the ability to run sensitivity analysis around key uncertainties/scenarios

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